For patients weighing 150 kg (330 pounds) or more, healthcare providers increase the dose to 1 gram to ensure adequate blood concentrations above the bacterial minimum inhibitory concentration for approximately 50 hours. This ceftriaxone monotherapy approach emerged after mounting azithromycin resistance prompted CDC to abandon dual-drug therapy in 2020, leaving gonorrhea treatment dependent on essentially one antibiotic classa precarious situation as resistance continues evolving globally
84 XuJ.XingX.-J.TianY.-S.PengR.-H.XueY.ZhaoW.et al (2015)
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Journal of Medicinal Chemistry, 64(15), 1118311194
A meaningful share of what users describe as "side effects" actually stems from other ingredients in the serum preservatives, fragrances, solvents, or high concentrations of exfoliating acids rather than the copper tripeptide in isolation
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